Presented at the ISOQOL 2025 conference in Milwaukee, this workshop provided participants with the rationale and value of utilizing personalized endpoints (why) and equipped them with the necessary knowledge and skills for practical implementation (how). Through a hands-on exercise, attendees learned to develop goal scales and calculate the GAS summary score. The workshop also illustrated the specific contexts where GAS is most suitable and effective (when/where), alongside strategies for overcoming common implementation challenges in both clinical practice and trials. The content below provides a preview of the topics covered during this engaging ISOQOL 2025 workshop.